Angiopoietin‐Like 2 Promotes Atherogenesis in Mice
نویسندگان
چکیده
منابع مشابه
Angiopoietin‐Like 2 Promotes Atherogenesis in Mice
BACKGROUND Angiopoietin like-2 (angptl2), a proinflammatory protein, is overexpressed in endothelial cells (ECs) from patients with coronary artery disease (CAD). Whether angptl2 contributes to atherogenesis is unknown. We tested the hypothesis that angptl2 promotes inflammation and leukocyte adhesion onto ECs, thereby accelerating atherogenesis in preatherosclerotic dyslipidemic mice. METHOD...
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BACKGROUND Placebo-controlled trials of nonsteroidal anti-inflammatory drugs selective for inhibition of cyclooxygenase-2 (COX-2) reveal an emergent cardiovascular hazard in patients selected for low risk of heart disease. Postnatal global deletion of COX-2 accelerates atherogenesis in hyperlipidemic mice, a process delayed by selective enzyme deletion in macrophages. METHODS AND RESULTS In t...
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ژورنال
عنوان ژورنال: Journal of the American Heart Association
سال: 2013
ISSN: 2047-9980,2047-9980
DOI: 10.1161/jaha.113.000201